Bone Abstracts

Synthetic glucocorticoids such as dexamethasone (Dex) are widely used for treatment of premature infants with chronic lung disease or respiratory distress syndrome or in allergic conditions such as asthma. Adverse effect of these treatments is glucocorticoids-induced osteoporosis. On the other hand there are functional foods, for instance 2-oxoglutaric acid (2-Ox) a precursor of hydroxyproline the prevailing amino acid in bone collagen, which reduce the risk of osteoporosis. T...

Surgical removal of the stomach (gastrectomy, Gx) leads to osteopenia in animals and in humans. In the rat, Gx causes loss of calvaria and trabecular bone, which can be reduced by 2-oxoglutaric acid (2-Ox), a precursor of hydroxyproline the most abundant amino acid in bone collagen. The purpose of this study was to investigate the effects (if any) of Gx on articular cartilage and if dietary 2-Ox can protects against eventual adverse effects of Gx. Twenty female Sprague–Da...

Our earlier results indicate that prenatal exposure to dexamethasone, synthetic glucocorticoid, may disturb metabolic processes in skeletal system with long-term consequences. Functional foods show a beneficial action that improve the state of health and reduce the risk of disease. The study was performed to determine whether 2-oxoglutaric acid (2-Ox) can abolish the growth inhibiting effect of prenatally administered dexamethasone (DEX) manifested in the growth plate and arti...

Acrylamide is a byproduct that forms when certain carbohydrate and aminoacid rich foods are fried, baked, or roasted at high temperatures (>120°C). Our earlier study showed that acrylamide altered the morphology and histology of the small intestinal wall damaging the intestinal barrier and reducing absorption surface. The study was performed to determine whether acrylamide influences gut-bone axis in foetus when administered to guinea pig during the last 35 days of pr...

Glucocorticoids are the most commonly used drugs in medical therapy, released in stress and necessary for normal development in both humans and animals.The aim of this study was to investigate the effect of prenatally administered dexamethasone (Dex), a synthetic glucocorticoid, on the histomorphometry of the femur in the offsprings of spiny mice, as a precocial species, characterized by high fertility, and the rapid development of the fetal, allowing th...

Alterations in fetal nutrition result in developmental adaptations that permanently alter the structure, physiology and metabolism of the offspring. β-hydroxy-β-methylbutyrate (HMB) is the bioactive metabolite of leucine responsible for inhibiting proteolysis and for modulating protein turnover in vitro and in vivo.The aim of the study was to determine the effect of maternal administration with HMB on mineralization, geometry ...

Tea is the second most consumed beverage in the world, next to water. The popularity of tea is determined by healthy properties connected with the presence of antioxidants, hence tea can be classified as functional food. Cadmium (Cd) and lead (Pb) are toxic metals commonly occurring in the human environment with exposure ~5 and 35 mg/kg Bw per week respectively.Thirty growing male Wistar rats (12 weeks old, 326.4±31.0 g) were used. Rat were fed ...

Zinc (Zn) has a number of key roles relating to cell signalling, cell activation, gene expression, protein synthesis, apoptosis and is crucial for the development of immune cells. Damage to the linings of the gastrointestinal tract is observed during Zn deficiency. Since a few years it has been suggested the existence of the novel interrelationship between bone and gut:gut–bone axis.The aim was to establish changes of morphological, geometric and me...